Current Position:Home>>Protein Products>>Recombinant Proteins>> Recombinant Human Osteoprotegerin/TNFRSF11B Protein (His Tag)

Recombinant Human Osteoprotegerin/TNFRSF11B Protein (His Tag)

Uniprot : O00300

Cat.No.:PKSH033573
Expression host: HEK293 Cells

Filter:

To Purchase PKSH033573

Size:

10μg
50μg

Price: $49

Qty:

Welcome to order from local distributors.

FAQs for Recombinant Proteins

Have Questions?

Add to cart Bulk request

For research use only. Order now, ship in 3 days

Description

Synonyms	Tumor necrosis factor receptor superfamily member 11B;Osteoclastogenesis inhibitory factor;Osteoprotegerin;TNFRSF11B;OCIF;OPG;PDB5;TR1
Species	Human
Expression_host	HEK293 Cells
Sequence	Glu22-Leu401
Accession	O00300
Mol_Mass	44.7 kDa
AP_Mol_Mass	57 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed man
Reconstitution	Please refer to the printed manual for detailed information.

Background

TNFRSF11B is a secreted protein; containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL; TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes; and a key regulator of inflammation; innate immunity; and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells; blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.

Related Products

Antibodies Proteins

Citations

Reviews/Q&A

Show all
Reviews
Q&A

T************iSubmitted [ Jul 10 2023 ]

Asked: I have a question about PB and NaCl concentration. Looking at my printed manual, it is recommended to prepare 0.25 mg/mL. In my case, I purchased 50 ug of Osteoprotegerin (PKSH033573), so I added 200 uL of sterile water. In this case, are concentrations of PB and NaCl in my solution 20 mM and 150 mM, respectively?

adminSubmitted [ Jul 10 2023 ]

Answered: Hello Ishii-san,thanks for your support.We will reply you by E-mail later.

... Show All Show Less

*Product Name:
*Catalog Number:
*Name:
*Email:
*Message:
*Country:
*When will you use it?	Within 1 month In 2 to 3 month In 4 to 6 month 6 months later
*Captcha:	Click to load Captcha