Recombinant Human Osteoprotegerin/TNFRSF11B Protein (His Tag)(Active)

    • Recombinant Human Osteoprotegerin / TNFRSF11B Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Osteoprotegerin / TNFRSF11B Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Osteoprotegerin / TNFRSF11B Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033573

      Synonyms:Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG;PDB5;TR1

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $49

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      Overview

      Synonyms Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG;PDB5;TR1
      Species Human
      Expression_host Human Cells
      Sequence Glu22-Leu401
      Accession O00300
      Mol_Mass 44.65 kDa
      AP_Mol_Mass 57 kDa
      Tag C-His
      Bio_Activity Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L‑929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 10.6 ng/ml.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.

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      MSDS for ELISA ISO 9001

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