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Recombinant Human Persephin/PSPN Protein (His Tag)

  • Cat.No.:PKSH033568

  • Expression host: E.coli

To Purchase PKSH033568

Size:
  • 10μg
  • 50μg
Price: $111
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Description

Synonyms Persephin; PSP; PSPN
Species Human
Expression_host E.coli
Sequence Ala61-Gly156
Accession O60542
Mol_Mass 10.4 kDa
AP_Mol_Mass 12 kDa
Tag N-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
Reconstitution Please refer to the printed manual for detailed information.

Background

Persephin is a secreted protein, belongs to the glial cell linederived neurotrophic factor (GDNF) family of the TGF-β superfamily. It shares 38-46% amino acid (aa) identity with family members GDNF, neurturin and artemin. It is expressed at very low levels in most tissues. Mature protein contains a signal sequence, a pro-domain and a 96 aa mature sequence with several cysteines that are conserved among family members. It circulates as an unglycosylated disulfide-linked homodimer. Like other GDNF family members, Persephin acts through engagement of GRFα4, a glycosylphosphatidylinositol (GPI)-linked GDNF receptor family Persephin is reported to promote both the survival and growth of central dopaminergic and motor neurons, and kidney development. These effects are correlated with the expression patterns of GFRα4, and RET.

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