Synonyms	Prolactin;PRL
Species	Human
Expression_host	E.coli
Sequence	Leu29-Cys227
Accession	P01236
Mol_Mass	23 kDa
AP_Mol_Mass	25 kDa
Tag	None

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 0.01 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM Nacl, 1mM EDTA, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the p
Reconstitution	Please refer to the printed manual for detailed information.

Background

Prolactin (PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation; but has pleiotropic effects in both males and females. Non-glycosylated prolactin is produced by the pituitary and packaged in storage granules before secretion; while glycosylated prolactin is reported to be constitutively secreted; have lower biological potency; and be removed from the circulation more quickly. Prolactin is synthesized mainly by the anterior pituitary in all mammals; where secretion is under tonic inhibition by hypothalamic dopamine. In humans; prolactin is also produced peripherally. Prolactin expression is low during early human pregnancy; but increases in late pregnancy. The prolactin receptor (PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. prolactin molecule is thought to bind two receptor molecules. In addition to its lactogenic activity; peripherally produced prolactin plays roles in breast and prostate cancer development; regulation of reproductive function; and immunoregulation.

Citations

Reviews/Q&A

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Reviews
Q&A

C***nSubmitted [ May 23 2023 ]

Asked: can this recombinant hormone activate other species\' prolactin receptor. Specillay we need to use on Mouse and rat

adminSubmitted [ May 23 2023 ]

Answered: For item PKSH033553, the bioactivity has not been verified, we are not sure whether it can activate prolactin receptor.

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