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Recombinant Human RNASET2 Protein (Human Cells, His Tag)

Uniprot : O00584
  • Cat.No.:PKSH033539

  • Expression host: Human Cells

To Purchase PKSH033539

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  • 10µg
  • 50µg
Price: $328
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Description

Synonyms Ribonuclease T2;3.1.27.-;Ribonuclease 6;RNASE6PL
Species Human
Expression_host Human Cells
Sequence Asp25-His256
Accession O00584
Mol_Mass 28.2 kDa
AP_Mol_Mass 40 kDa
Tag C-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM TrisHcl, 150mM NaCl,20%Glycerol,pH7.5.
Reconstitution Please refer to the printed manual for detailed information.

Background

RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

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