Recombinant Human RNASET2 Protein (Human Cells, His Tag)

    • Recombinant Human RNASET2 / Ribonuclease T2 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human RNASET2 / Ribonuclease T2 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human RNASET2 / Ribonuclease T2 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033539

      Synonyms:Ribonuclease T2;3.1.27.-;Ribonuclease 6;RNASE6PL

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $328

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Ribonuclease T2;3.1.27.-;Ribonuclease 6;RNASE6PL
      Species Human
      Expression_host Human Cells
      Sequence Asp25-His256
      Accession O00584
      Mol_Mass 28.2 kDa
      AP_Mol_Mass 40 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μm filtered solution of 20mM TrisHcl, 150mM NaCl,20%Glycerol,pH7.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

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