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Recombinant Human SIRPB2 (C-Fc)

Cat:PKSH033926
Manual MSDS

Price: $ 277

Price: $ 93

Size:
50μg 10μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: Q5JXA9
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Product Details
Synonyms dJ776F14.2;PTPN1L;PTPNS1L3;Signal-Regulatory Protein Beta 2;Signal-Regulatory Protein Beta-2;SIRP beta 2;SIRP-beta-2;SIRPG
Species Human
Expression Host HEK293 Cells
Sequence Gln33-Gly287
Accession Q5JXA9
Calculated Molecular Weight 55.2 kDa
Observed Molecular Weight 80-95 kDa
Tag C-Fc
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.