Recombinant Human STAT6 Protein (E.coli, His Tag)

    • Recombinant Human STAT6 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human STAT6 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human STAT6 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033528

      Synonyms:Signal Transducer and Activator of Transcription 6; IL-4 Stat; STAT6;IL-4-STAT;STAT6B;STAT6C

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $178

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      Overview

      Synonyms Signal Transducer and Activator of Transcription 6; IL-4 Stat; STAT6;IL-4-STAT;STAT6B;STAT6C
      Species Human
      Expression_host E.coli
      Sequence Ser627-Ser837
      Accession P42226
      Mol_Mass 23.9 kDa
      AP_Mol_Mass 28 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 has been shown to interact with EP300, CREB-binding protein, NFKB1, Nuclear receptor coactivator 1, IRF4 and SND1.

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