Recombinant Human STK16 / PKL12 / MPSK Protein (His & NusA tag)

    • Recombinant Human STK16 / PKL12 / MPSK Protein (His & NusA tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human STK16 / PKL12 / MPSK Protein (His & NusA tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human STK16 / PKL12 / MPSK Protein (His & NusA tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030340

      Synonyms:KRCT;MPSK;PKL12;TSF1

      Size:
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms KRCT;MPSK;PKL12;TSF1
      Species Human
      Expression_host E.coli
      Sequence Met 1-Ile 305
      Accession AAH02618.1
      Mol_Mass 92 kDa
      AP_Mol_Mass 105 kDa
      Tag N-His & NusA

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin Please contact us for more information.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein which is ubiquitously expressed at very low levels. STK16 / MPSK1 belongs to the protein kinase superfamily and Ser/Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Some factors such as Smads (Sma and Mad proteins) and TGF-beta activating kinase 1 have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. STK16 / MPSK1 is an unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. STK16 / MPSK1 is a protein kinase that act on both serine and threonine residues. STK16 / MPSK1 possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. STK16 / MPSK1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. STK16 / MPSK1 mRNA as well as its protein level were stimulated by TGF-beta treatment.

      SDS-PAGE

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      MSDS for ELISA

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