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Recombinant Human SULT1E1/ST1E1 Protein (His Tag) (PKSH031173)

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50μg $ 680.00
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For research use only.

Synonyms EST, EST-1, MGC34459, ST1E1, STE
Species Human
Expression Host E.coli
Sequence Asn 2-Ile 294
Accession NP_005411.1
Calculated Molecular Weight 36.0 kDa
Observed Molecular Weight 33 kDa
Tag N-His
Bio-activity Not validated for activity
Form Liquid
Purity > 92 % as determined by reducing SDS-PAGE.
Endotoxin Please contact us for more information.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as sterile 20mM Tris 0.5M NaCl, 20% glycerol, pH 8.0
Background Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme which belongs to thesulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1E1 may control the level of the estrogen receptor by sulfurylating free estradiol. SULT1E1 maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. SULT1E1 also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. SULT1E1 is a key enzyme in estrogen homeostasis. It plays a central role in the prevention and development of human disease.
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