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Recombinant Human TIMP2/TIMP-2 Protein (Fc Tag)

Cat:PKSH030472
Manual MSDS

Price: $ 486

Size:
20μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: NP_003246.1
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For research use only. Order now, ship in 3 days

Product Details
Synonyms Metalloproteinase Inhibitor 2;CSC-21K;Tissue Inhibitor of Metalloproteinases 2;CSC-21K;DDC8
Species Human
Expression Host HEK293 Cells
Sequence Cys 27-Pro 220
Accession NP_003246.1
Calculated Molecular Weight 48.0 kDa
Observed Molecular Weight 48 kDa
Tag N-hFc
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment.