Recombinant Human TIMP2 / TIMP-2 Protein (Fc tag)

    • Recombinant Human TIMP2 / TIMP-2 Protein (Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human TIMP2 / TIMP-2 Protein (Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human TIMP2 / TIMP-2 Protein (Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030472

      Synonyms:CSC-21K;DDC8

      Size:
      • 10 µg
      • 20 µg
      Qty:
      - +
      Price: $365

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CSC-21K;DDC8
      Species Human
      Expression_host HEK293 Cells
      Sequence Cys 27-Pro 220
      Accession NP_003246.1
      Mol_Mass 48 kDa
      AP_Mol_Mass 48 kDa
      Tag N-Fc

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment.

      SDS-PAGE

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