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Recombinant Human TRAIL R3/TNFRSF10C Protein (Fc & His Tag)

Uniprot : O14798

Cat.No.:PKSH033129
Expression host: HEK293 Cells

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Description

Synonyms	Tumor Necrosis Factor Receptor Superfamily Member 10C;Antagonist Decoy Receptor for TRAIL/Apo-2L;Decoy TRAIL Receptor Without Death Domain;Decoy Receptor 1;DcR1;Lymphocyte Inhibitor of TRAIL;TNF-Related Apoptosis-Inducing Ligand Receptor 3;TRAIL Receptor 3;TRAIL-R3;TRAIL Receptor Without an Intracellular Domain;CD263;TNFRSF10C;DCR1;LIT;TRAILR3;TRID
Species	Human
Expression_host	HEK293 Cells
Sequence	Ala26-Ala221
Accession	O14798
Mol_Mass	48.7 kDa
AP_Mol_Mass	90 kDa
Tag	C-Fc-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains; lacks the intracellular signaling domain. As a result; binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.

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