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Recombinant Human TRAIL R4/TNFRSF10D Protein (Fc Tag)

Uniprot : Q9UBN6

Cat.No.:PKSH033488
Expression host: HEK293 Cells

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Description

Synonyms	Tumor necrosis factor receptor superfamily member 10D;Decoy receptor 2;DcR2;TNF-related apoptosis-inducing ligand receptor 4;TRAIL receptor 4;TRAIL-R4;TRAIL receptor with a truncated death domain;CD264;TNFRSF10D;DCR2;TRAILR4;TRUNDD
Species	Human
Expression_host	HEK293 Cells
Sequence	Ala56-His211
Accession	Q9UBN6
Mol_Mass	43.4 kDa
AP_Mol_Mass	50-70 kDa
Tag	C-Fc

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Human TRAIL R4 is a type 1, TNF R family membrane protein, which is a receptor for TRAIL (APO2 ligand). TRAIL R4 contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. In the new TNF superfamily nomenclature, TRAIL R4 is referred to as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.

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