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Recombinant Human VEGF165/VEGFA Protein (Active)

  • Cat.No.:PKSH033475

  • Expression host: Human Cells

To Purchase PKSH033475

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  • 10μg
  • 50μg
Price: $178
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Description

Synonyms MVCD1;VEGF;VEGF165;VPF;Vascular Endothelial Growth Factor Isoform 165
Species Human
Expression_host Human Cells
Sequence Ala27-Arg191
Accession P15692-4
Mol_Mass 19.1 kDa
AP_Mol_Mass 18-22 kDa
Bio_Activity Immobilized Human VEGF165 at 10μg/ml (100 μl/well) can bind Human VEGFR2, The ED50 of Human VEGF165 is 433.6 ng/ml.

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Reconstitution Please refer to the printed manual for detailed information.

Background

Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimulates the cellular response through binding to tyrosine kinase receptors VEGFR1 and VEGFR2 on the cell surface. It is widely accepted that VEGFR2 mediate almost all of the known cellular responses to VEGF while the function of VEGFR1 is less defined and is thought to modulate the VEGFR2 signaling.

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