Recombinant Mouse BMPR1B/ALK-6 Protein (Fc Tag)

    • Mouse ALK-6 / BMPR1B Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Mouse ALK-6 / BMPR1B Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Mouse ALK-6 / BMPR1B Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040925

      Synonyms:Acvrlk6;AI385617;ALK-6;Alk6;AV355320;BMPR-1B;BMPR-IB;CFK-43a;SKR6

      Size:
      • 20 μg
      • 100 μg
      Qty:
      - +
      Price: $164

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Acvrlk6;AI385617;ALK-6;Alk6;AV355320;BMPR-1B;BMPR-IB;CFK-43a;SKR6
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Lys14-Lys126
      Accession NP_031586.1
      Mol_Mass 39.4 kDa
      Tag C-Fc

      Properties

      Purity > (88.3+9.9) % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

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