Recombinant Mouse Cystatin 7/CST7 Protein (Fc Tag)(Active)

    • Recombinant Mouse Cystatin 7 / CST7 Protein (Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse Cystatin 7 / CST7 Protein (Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse Cystatin 7 / CST7 Protein (Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040785

      Synonyms:Cystatin-F; Cystatin-like Metastasis-Associated Protein; Leukocystatin; CMAP; Cystatin-7; Cst7

      Size:
      • 10 μg
      • 20 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Cystatin-F; Cystatin-like Metastasis-Associated Protein; Leukocystatin; CMAP; Cystatin-7; Cst7
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met1-Gln144
      Accession O89098
      Mol_Mass 41.4 kDa
      AP_Mol_Mass 42 kDa
      Tag C-Fc
      Bio_Activity Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenic peptide substrate Z-LR-AMC, R&D Systems, Catalog # ES008.The IC50 is < 6 nM.

      Properties

      Purity > 93 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 25mM Tris, 0.15M NaCl, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.

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