Recombinant Mouse EDA2R/TNFRSF27 Protein (Fc Tag)

    • Recombinant Mouse EDA2R / TNFRSF27 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse EDA2R / TNFRSF27 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse EDA2R / TNFRSF27 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041342

      Synonyms:Ectodysplasin A2 receptor; EDA-A2 receptor; EDA-A2R; Tumor necrosis factor receptor superfamily member XEDAR; Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor;EDAA2R; TNFRSF27; XEDAR;EDAR2

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $92

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      Overview

      Synonyms Ectodysplasin A2 receptor; EDA-A2 receptor; EDA-A2R; Tumor necrosis factor receptor superfamily member XEDAR; Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor;EDAA2R; TNFRSF27; XEDAR;EDAR2
      Species Mouse
      Expression_host Human Cells
      Sequence Met1-Thr138
      Accession Q8BX35
      Mol_Mass 42.5 kDa
      AP_Mol_Mass 50-60 kDa
      Tag C-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA-A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down-regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA-A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.

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