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Recombinant Mouse EDA2R/TNFRSF27 Protein (Fc Tag)

  • Cat.No.:PKSM041342

  • Expression host: Human Cells

To Purchase PKSM041342

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  • 10μg
  • 50μg
Price: $92
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Description

Synonyms Ectodysplasin A2 receptor; EDA-A2 receptor; EDA-A2R; Tumor necrosis factor receptor superfamily member XEDAR; Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor;EDAA2R; TNFRSF27; XEDAR;EDAR2
Species Mouse
Expression_host Human Cells
Sequence Met1-Thr138
Accession Q8BX35
Mol_Mass 42.5 kDa
AP_Mol_Mass 50-60 kDa
Tag C-Fc

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA-A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down-regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA-A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.

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