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Recombinant Mouse FOLR1 Protein (aa 25-232, His Tag)

Cat:PKSM041337
Manual MSDS

Price: $ 268

Price: $ 92

Size:
50μg 10μg
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  • Expression Host: HEK293 Cells
  • Accession: P35846
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Product Details
Synonyms Adult folate-binding protein;FBP;folate binding protein;folate receptor 1 (adult);Folate receptor 1;folate receptor alpha;Folate receptor;adult;Folbp1;FOLR;FOLR1;FR-alpha;KB cells FBP;MOv18;Ovarian tumor-associated antigen MOv18;FBP1;Folbp-1
Species Mouse
Expression Host HEK293 Cells
Sequence Thr25-Ser232
Accession P35846
Calculated Molecular Weight 25.3 kDa
Observed Molecular Weight 33-37 kDa
Tag C-His
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Folate Receptor alpha belongs to the folate receptor family and it is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates.Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 can be detected in kidney proximal tubules. It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.