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Recombinant Mouse Hemopexin/HPX Protein (His Tag)

Cat:PKSM041334
Manual MSDS

Price: $ 447

Price: $ 257

Size:
50μg 10μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: Q91X72
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Product Details
Synonyms Hemopexin;Hpx;Hpxn
Species Mouse
Expression Host HEK293 Cells
Sequence Ser24-Gln460
Accession Q91X72
Calculated Molecular Weight 49.8 kDa
Observed Molecular Weight 65-90 kDa
Tag C-His
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Reconstitution Not Applicable
Background Hemopexin (HPX) is plasma glycoprotein belongs to the family of the acute-phase proteins whose synthesis is induced after an inflammatory event. Hemopexin with two four-bladed beta -propeller folds has been found in other proteins including collagenases and provides sites for protein-protein interactions. The liver is the major synthesizing organ. Hemopexin participates in maintaining and recycling the iron pool by utilizing its high binding affinity toward heme composed of protoporphyrin IX and iron. It also functions in preventing oxidation caused by heme after hemolysis. Hydrophobic heme molecules can intercalate into lipid membranes and participate in the oxidation of lipid membrane components through the Fenton reaction resulting in lipid peroxidation. Hemopexin undergoes a conformational change upon the binding of heme. The conformational change allows hemopexin to interact with a specific receptor, forming a complex which is then internalized. Heme concentrations in plasma increase after hemolysis, which is associated with several pathological conditions such as reperfusion injury and ischemia.