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Recombinant Mouse Hemopexin/HPX Protein (His Tag)

  • Cat.No.:PKSM041334

  • Expression host: Human Cells

To Purchase PKSM041334

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  • 10μg
  • 50μg
Price: $257
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Description

Synonyms Hemopexin;Hpx;Hpxn
Species Mouse
Expression_host Human Cells
Sequence Ser24-Gln460
Accession Q91X72
Mol_Mass 49.8 kDa
AP_Mol_Mass 65-90 kDa
Tag C-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Reconstitution Please refer to the printed manual for detailed information.

Background

Hemopexin (HPX) is plasma glycoprotein belongs to the family of the acute-phase proteins whose synthesis is induced after an inflammatory event. Hemopexin with two four-bladed beta -propeller folds has been found in other proteins including collagenases and provides sites for protein-protein interactions. The liver is the major synthesizing organ. Hemopexin participates in maintaining and recycling the iron pool by utilizing its high binding affinity toward heme composed of protoporphyrin IX and iron. It also functions in preventing oxidation caused by heme after hemolysis. Hydrophobic heme molecules can intercalate into lipid membranes and participate in the oxidation of lipid membrane components through the Fenton reaction resulting in lipid peroxidation. Hemopexin undergoes a conformational change upon the binding of heme. The conformational change allows hemopexin to interact with a specific receptor, forming a complex which is then internalized. Heme concentrations in plasma increase after hemolysis, which is associated with several pathological conditions such as reperfusion injury and ischemia.

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