Recombinant Mouse ICOS Ligand/ICOSL Protein (His Tag)(Active)

    • Recombinant Mouse ICOS Ligand / B7-H2 / ICOSLG Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    <
    >
    • Recombinant Mouse ICOS Ligand / B7-H2 / ICOSLG Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse ICOS Ligand / B7-H2 / ICOSLG Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040815

      Synonyms:Icosl, AU044799, B7-H2, B7RP-1, B7h, BG071784, GI50, GL50, GL50-B, ICOS-L, KIAA0653, LICOS, Ly115l, Mkiaa0653

      Size:
      • 100 μg
      • 200 μg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Icosl, AU044799, B7-H2, B7RP-1, B7h, BG071784, GI50, GL50, GL50-B, ICOS-L, KIAA0653, LICOS, Ly115l, Mkiaa0653
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Lys 279
      Accession NP_056605.1
      Application Functional ELISA
      Mol_Mass 27.8 kDa
      AP_Mol_Mass 45-55 kDa
      Tag C-His
      Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized mouse B7-H2 at 1 µg/ml (100 μl/well) can bind human ICOS with a linear range of 40-1000 ng/ml.

      Properties

      Purity > 95 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

      Image

      submit review
      • Show all (0)
      • Reviews (0)
      • Q&A (0)
      ... Show All Show Less
      MSDS for ELISA ISO 9001

      Browsing History


        People Also Bought

        Apply for 24T ELISA Kit
        *Product Name:
        *Catalog Number:
        Size:
        *Name:
        *Email:
        *Phone:
        *Message:
        *Country:
        How do you know
        Elabscience:

        *Verification code: