Recombinant Mouse IGFBP-7/IGFBP7 Protein (His Tag)

    • Recombinant Mouse IGFBP-7 / IGFBP7 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse IGFBP-7 / IGFBP7 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse IGFBP-7 / IGFBP7 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041324

      Synonyms:Insulin-like growth factor-binding protein 7;IGFBP7;IGF-binding protein 7;IGFBP-rP1;MAC25 protein;Tumor-derived adhesion factor;TAF;Igfbp7;IBP-7;AGM;Fstl2;Mac25

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $129

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      Overview

      Synonyms Insulin-like growth factor-binding protein 7;IGFBP7;IGF-binding protein 7;IGFBP-rP1;MAC25 protein;Tumor-derived adhesion factor;TAF;Igfbp7;IBP-7;AGM;Fstl2;Mac25
      Species Mouse
      Expression_host Human Cells
      Sequence Ser26-Leu281
      Accession Q61581
      Mol_Mass 27.2 kDa
      AP_Mol_Mass 32-35 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,150mM Nacl,pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. It binds IGF and insulin with very low affinity and has been shown to enhance the mitogenic actions of IGF and insulin. IGFBP7 also has IGF/insulin-independent activities. It interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, promotes cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. It modulates tumor cell growth and has also been implicated in angiogenesis.

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      MSDS for ELISA ISO 9001

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