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Recombinant Mouse IL-23/Interleukin-23(IL23A&IL12B) Protein (His Tag)

  • Cat.No.:PKSM041315

  • Expression host: Human Cells

To Purchase PKSM041315

Size:
  • 10μg
  • 50μg
Price: $214
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Description

Synonyms SGRF;IL-23p19;CLMF p40;IL-12 subunit p40;NKSF2
Species Mouse
Expression_host Human Cells
Sequence Val22-Ala196&Met23-Ser335
Accession Q9EQ14&P43432
Mol_Mass 9.7&36.8 kDa
AP_Mol_Mass 40-55 kDa
Tag C-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.

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