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Recombinant Mouse MAG/Siglec-4a Protein (His Tag)

  • Cat.No.:PKSM041303

  • Expression host: Human Cells

To Purchase PKSM041303

Size:
  • 10μg
  • 50μg
Price: $86
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Description

Synonyms Myelin-Associated Glycoprotein;MAG;Siglec-4a
Species Mouse
Expression_host Human Cells
Sequence Gly20-Pro516
Accession P20917
Mol_Mass 55.7 kDa
AP_Mol_Mass 70-120 kDa
Tag C-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Myelin-Associated Glycoprotein (MAG, Siglec-4a), is a type I transmembrane glycoprotein belonging to the Siglec family. It is composed of an extracellular segment containing five Ig-like domains, a single transmembrane segment, and a cytoplasmic domain. Mouse MAG shares 95% and 99% aa sequence identity with human and rat MAG, respectively. MAG functions as an adhesion molecule during neural development. It preferentially binds to alpha -2,3-linked sialic acid terminal structures found on cell surface molecules. MAG is selectively expressed by myelinating oligodendrocytes and Schwann cells and plays an important role in axon-myelin stability. MAG is also reported to regulate the axon cytoskeleton and support the distribution of axon molecules at the nodes of Ranvier. In addition, it has been identified as a major inhibitor of neurite outgrowth.

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