Recombinant Mouse MAG/Siglec-4a Protein (His Tag)

    • Recombinant Mouse MAG / Siglec-4a Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse MAG / Siglec-4a Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse MAG / Siglec-4a Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041303

      Synonyms:Myelin-Associated Glycoprotein;MAG;Siglec-4a

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $86

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      Overview

      Synonyms Myelin-Associated Glycoprotein;MAG;Siglec-4a
      Species Mouse
      Expression_host Human Cells
      Sequence Gly20-Pro516
      Accession P20917
      Mol_Mass 55.7 kDa
      AP_Mol_Mass 70-120 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Myelin-Associated Glycoprotein (MAG, Siglec-4a), is a type I transmembrane glycoprotein belonging to the Siglec family. It is composed of an extracellular segment containing five Ig-like domains, a single transmembrane segment, and a cytoplasmic domain. Mouse MAG shares 95% and 99% aa sequence identity with human and rat MAG, respectively. MAG functions as an adhesion molecule during neural development. It preferentially binds to alpha -2,3-linked sialic acid terminal structures found on cell surface molecules. MAG is selectively expressed by myelinating oligodendrocytes and Schwann cells and plays an important role in axon-myelin stability. MAG is also reported to regulate the axon cytoskeleton and support the distribution of axon molecules at the nodes of Ranvier. In addition, it has been identified as a major inhibitor of neurite outgrowth.

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