Recombinant Mouse Mesothelin/MSLN Protein (His Tag)

    • Recombinant Mouse MSLN / Mesothelin (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse MSLN / Mesothelin (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse MSLN / Mesothelin (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041304

      Synonyms:Mesothelin; Msln; Mes; Mpf; CAK1; MSLN

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

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      Overview

      Synonyms Mesothelin; Msln; Mes; Mpf; CAK1; MSLN
      Species Mouse
      Expression_host Human Cells
      Sequence Asp298-Ser600
      Accession Q61468
      Mol_Mass 35 kDa
      AP_Mol_Mass 30-38 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Mesothelin is derived from a 70 kDa precursor that also includes Megakaryocyte Potentiating Factor (MPF).The 70 kDa precursor is expressed on the cell surface where it is cleaved at a dibasic proteolytic site to release the 32 kDa glycosylated MPF. MPF is a cytokine that potentiates IL3 induced megakaryocyte colony formation. The term Mesothelin refers to the 40 kDa glycosylated protein which remains attached to the cell surface via a GPI linkage. Mesothelin is over expressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The interaction between mesothelin and MUC16 (also known as CA125) may facilitate the implantation and peritoneal spread of tumors by cell adhesion. The region (296-359) consisting of 64 amino acids at the N-terminal of cell surface mesothelin is the functional binding domain for MUC16. Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. A soluble form of Mesothelin, with its GPI anchor intact, is released from tumor cells and binds to MMR/CD206 on macrophages.

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      MSDS for ELISA ISO 9001

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