Recombinant Mouse Nogo Receptor/NgR Protein (His & Fc Tag)(Active)

    • Recombinant Mouse Nogo Receptor / NOGOR / RTN4R Protein (His & Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse Nogo Receptor / NOGOR / RTN4R Protein (His & Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse Nogo Receptor / NOGOR / RTN4R Protein (His & Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040862

      Synonyms:NgR;NgR1;NOGOR;Rtn4r

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms NgR;NgR1;NOGOR;Rtn4r
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Ser 447
      Accession NP_075358.1
      Application Functional ELISA
      Mol_Mass 73.8 kDa
      AP_Mol_Mass 95-100 kDa
      Tag C-His-Fc
      Bio_Activity 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant Mouse RTN4R Fc Chimera at 2 µg/ml (100 μl/well) can bind biotinylated human RTN4 (GST Tag) with a linear range of 0.16-2.5 µg/ml.

      Properties

      Purity > 85 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.

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      MSDS for ELISA ISO 9001

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