Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein (His Tag)
Price: $ 262
Price: $ 98
Size:
50μg
10μg
Quantity:
- Expression Host: HEK293 Cells
- Accession: P63089
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Product Details
Synonyms | Pleiotrophin;PTN;Heparin-binding brain mitogen;HBBM;Heparin-binding growth factor 8;HBGF-8;Osteoblast-specific factor 1;OSF-1;HARP;HB-GAM;HBBN;HBNF;OSF;Osf-1;Osf1 |
Species | Mouse |
Expression Host | HEK293 Cells |
Sequence | Gly33-Asp168 |
Accession | P63089 |
Calculated Molecular Weight | 16.1 kDa |
Observed Molecular Weight | 18 kDa |
Tag | C-His |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
Reconstitution | Please refer to the printed manual for detailed information. |
Background | Pleiotrophin (PTN) is an secreted, strongly heparinbinding,developmentally regulated cytokine. PTN and midkine share50% amino acid (aa) sequence identity, share some functions, and constitute a family. PTN is a highly conserved protein? human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity orgreater. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates its phosphatase activity, which allows increased tyrosine phosphorylation of its substrates. Increased expression of PTN is correlated withneuronal development or stresses such as brain ischemia and Parkinson’s disease. |