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Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein (His Tag)

  • Cat.No.:PKSM041292

  • Expression host: Human Cells

To Purchase PKSM041292

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  • 10μg
  • 50μg
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Description

Synonyms Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Osteoblast-specific factor 1; OSF-1;HARP;HB-GAM;HBBN;HBNF;OSF;Osf-1;Osf1
Species Mouse
Expression_host Human Cells
Sequence Gly33-Asp168
Accession P63089
Mol_Mass 16.1 kDa
AP_Mol_Mass 18 kDa
Tag C-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Pleiotrophin (PTN) is an secreted, strongly heparinbinding,developmentally regulated cytokine. PTN and midkine share50% amino acid (aa) sequence identity, share some functions, and constitute a family. PTN is a highly conserved protein? human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity orgreater. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates its phosphatase activity, which allows increased tyrosine phosphorylation of its substrates. Increased expression of PTN is correlated withneuronal development or stresses such as brain ischemia and Parkinson’s disease.

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