Recombinant Mouse PRLR/Prolactin Receptor Protein (Fc Tag)

    • Recombinant Mouse Prolactin Receptor / PRLR Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse Prolactin Receptor / PRLR Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse Prolactin Receptor / PRLR Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041287

      Synonyms:Prolactin receptor; PRL-R; Prlr; Prolactin R; PRLR

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $92

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      Overview

      Synonyms Prolactin receptor; PRL-R; Prlr; Prolactin R; PRLR
      Species Mouse
      Expression_host Human Cells
      Sequence Gln20-Asp229
      Accession Q08501
      Mol_Mass 51.7 kDa
      AP_Mol_Mass 62-88 kDa
      Tag C-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human breast tissue, and in most breast cancer cells. PRLR contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region required for the activation of the Jak2–Stat5 signal transduction pathway by Prl which is essential for transcriptional activation of all known prolactin regulated genes. PRLRs have also been observed in ovarian follicular cells of mice, pigs, sheep, deer, and humans, as well as in luteal tissue in cow and horse ovaries. Furthermore, PRLR knockout mice exhibit failure of embryonic implantation, reduced number of mature oocytes, and low fertilization rates. Knockout females also display a reduced number of primary follicles.

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