Recombinant Mouse TGFBR2 Protein (His Tag)
Price: $ 214
Price: $ 92
Size:
50μg
10μg
Quantity:
- Expression Host: HEK293 Cells
- Accession: Q62312-2
- Applications: Cell culture
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Product Details
Synonyms | TGF-beta receptor type-2;TGFR-2;TGF-beta type II receptor;Transforming growth factor-beta receptor type II;TGF-beta receptor type II;TbetaR-II;Tgfbr2 |
Species | Mouse |
Expression Host | HEK293 Cells |
Sequence | Ile24-Asp159 |
Accession | Q62312-2 |
Calculated Molecular Weight | 16.2 kDa |
Observed Molecular Weight | 25-38 kDa |
Tag | C-His |
Bio-activity | Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells.The ED<sub>50</sub> for this effect is 1680.39ng/ml in the presence of 1ng/ml of recombinant human TGF-beta 1. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
Reconstitution | Please refer to the printed manual for detailed information. |
Background | Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinity cell surface receptors: TGF-β receptor type I (TGF-β-RI), TGF-β receptor type II (TGF-β-RII), and TGF-ββ receptor type III (TGF-β-RIII). TGF-β RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-β) receptor subfamily. TGF-β RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. |