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Recombinant Mouse TGFBR2 Protein (His Tag)

Cat:PKSM041169
Manual MSDS

Price: $ 214

Price: $ 92

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50μg 10μg
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  • Expression Host: HEK293 Cells
  • Accession: Q62312-2
  • Applications: Cell culture
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Product Details
Synonyms TGF-beta receptor type-2;TGFR-2;TGF-beta type II receptor;Transforming growth factor-beta receptor type II;TGF-beta receptor type II;TbetaR-II;Tgfbr2
Species Mouse
Expression Host HEK293 Cells
Sequence Ile24-Asp159
Accession Q62312-2
Calculated Molecular Weight 16.2 kDa
Observed Molecular Weight 25-38 kDa
Tag C-His
Bio-activity Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells.The ED<sub>50</sub> for this effect is 1680.39ng/ml in the presence of 1ng/ml of recombinant human TGF-beta 1.
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinity cell surface receptors: TGF-β receptor type I (TGF-β-RI), TGF-β receptor type II (TGF-β-RII), and TGF-ββ receptor type III (TGF-β-RIII). TGF-β RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-β) receptor subfamily. TGF-β RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.