Recombinant Mouse TIM-3/HAVCR2 Protein (Fc Tag)(Active)

    • Recombinant Mouse TIM-3 / HAVCR2 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse TIM-3 / HAVCR2 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse TIM-3 / HAVCR2 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041277

      Synonyms:Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; Timd3

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $92

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      Overview

      Synonyms Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; Timd3
      Species Mouse
      Expression_host Human Cells
      Sequence Arg20-Arg191
      Accession Q8VIM0
      Application Functional ELISA
      Mol_Mass 46.3 kDa
      AP_Mol_Mass 50-80 kDa
      Tag C-Fc
      Bio_Activity Immobilized Galectin 9-His(Cat: PKSH032470) at 2μg/ml(100 μl/well) can bind Mouse TIM-Fc. The ED50 of Mouse TIM-Fc is 4.053ug/ml .

      Properties

      Purity > 90% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

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      MSDS for ELISA ISO 9001

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