Recombinant Mouse TNFRSF17/BCMA Protein (His & Fc Tag)(Active)

    • Recombinant Mouse TNFRSF17 / BCMA Protein (His & Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse TNFRSF17 / BCMA Protein (His & Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse TNFRSF17 / BCMA Protein (His & Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040938

      Synonyms:Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17;BCM;BCMA;Tnfrsf13;Tnfrsf13a

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17;BCM;BCMA;Tnfrsf13;Tnfrsf13a
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Thr 49
      Accession NP_035738.1
      Application Functional ELISA
      Mol_Mass 33.7 kDa
      AP_Mol_Mass 35-48 kDa
      Tag C-His-Fc
      Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized human BAFF at 10 µg/ml (100 μl/well) can bind mouse BCMA-Fch, The EC50 of mouse BCMA-Fch is 0.02-0.06 µg/mL.

      Properties

      Purity > 90 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

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