English Toll-free:1-888-852-8623 or Contact Us
Keyword cannot be empty !

Recombinant Rat IL17RA Protein (Fc Tag)

Cat:PKSR030332
Manual MSDS

Price: $ 940

Size:
100μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: NP_001101353.2
  • Applications: ELISA
Add to cart

For research use only. Order now, ship in 3 days

Product Details
Synonyms IL17RA
Species Rat
Expression Host HEK293 Cells
Sequence Met1-Pro320
Accession NP_001101353.2
Calculated Molecular Weight 59.7 kDa
Observed Molecular Weight 68-102 kDa
Tag C-hFc
Bio-activity Immobilized mouse Il17A at 10 μg/ml (100 μl/well) can bind Rat IL17RA, The EC50 of RatIL17RA is 12.0-29.0 ng/ml.
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.