English Toll-free:1-888-852-8623 or Contact Us
Keyword cannot be empty !

Recombinant Rat IL6RA/CD126 Protein (ECD, His Tag)

Cat:PKSR030142
Manual MSDS

Price: $ 732

Size:
50μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: NP_058716.2
  • Applications: ELISA
Add to cart

For research use only. Order now, ship in 3 days

Product Details
Synonyms Il6ra;IL-6R
Species Rat
Expression Host HEK293 Cells
Sequence Met1-Pro364
Accession NP_058716.2
Calculated Molecular Weight 39.5 kDa
Tag C-His
Bio-activity Measured by its ability to bind human IL6 in functional ELISA.
Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.