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Recombinant Rat RANK/TNFRSF11A Protein (Fc Tag)

  • Cat.No.:PKSR030345

  • Expression host: HEK293 Cells

To Purchase PKSR030345

Size:
  • 100μg
  • 200μg
Price: $486
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Description

Synonyms RGD1563614
Species Rat
Expression_host HEK293 Cells
Sequence Met1-Pro213
Accession NP_001258164.1
Mol_Mass 47.1 kDa
AP_Mol_Mass 61 kDa
Tag C-Fc

Properties

Purity > 80 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg of the protein as determined by the LAL method
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

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