RPSA Polyclonal Antibody

Uniprot : P08865
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14216

      Synonyms:34/67 kDa laminin receptor,37 kDa laminin receptor precursor,37/67 kDa laminin receptor,37LRP,40S ribosomal protein SA,67 kDa laminin receptor,67LR,Colon carcinoma laminin binding protein,Colon carcinoma laminin-binding protein,LAMBR,Laminin receptor 1,Laminin-binding protein precursor p40,LAMR 1,LamR,LAMR1,LBP,LBP/p40,LRP,LRP/LR,Multidrug resistance associated protein MGr1 Ag,Multidrug resistance associated protein MGr1Ag,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,p40,Ribosomal Protein SA,rpsA,RSSA,SA

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 34/67 kDa laminin receptor,37 kDa laminin receptor precursor,37/67 kDa laminin receptor,37LRP,40S ribosomal protein SA,67 kDa laminin receptor,67LR,Colon carcinoma laminin binding protein,Colon carcinoma laminin-binding protein,LAMBR,Laminin receptor 1,Laminin-binding protein precursor p40,LAMR 1,LamR,LAMR1,LBP,LBP/p40,LRP,LRP/LR,Multidrug resistance associated protein MGr1 Ag,Multidrug resistance associated protein MGr1Ag,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,p40,Ribosomal Protein SA,rpsA,RSSA,SA
      Swissprot P08865
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human RPSA
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300
      Concentration 0.5 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cell membrane. Cytoplasm. Nucleus. 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene

      Images

      Western Blot analysis of A549, NIH/3T3 and 293T cell,Human hepatocellular carcinoma tissue and hela cell using RPSA Polyclonal Antibody at dilution of 1:433.3

      Immunohistochemistry of paraffin-embedded Human thyroid cancer using RPSA Polyclonal Antibody at dilution of 1:60

      Immunohistochemistry of paraffin-embedded Human brain using RPSA Polyclonal Antibody at dilution of 1:60

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