STAT3 Monoclonal Antibody

Uniprot : P40763
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22166

      Synonyms:1110034C02Rik,Acute Phase Response Factor,Acute-phase response factor,ADMIO,APRF,AW109958,DNA binding protein APRF,FLJ20882,HIES,MGC16063,Signal transducer and activator of transcription 3 (acute phase response factor),Signal transducer and activator of transcription 3,STAT 3,Stat3,STAT3

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H,M,R

      Applications: WB,IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 1110034C02Rik,Acute Phase Response Factor,Acute-phase response factor,ADMIO,APRF,AW109958,DNA binding protein APRF,FLJ20882,HIES,MGC16063,Signal transducer and activator of transcription 3 (acute phase response factor),Signal transducer and activator of transcription 3,STAT 3,Stat3,STAT3
      Swissprot P40763
      Source Mouse
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant Protein
      Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R217)
      Recommended dilution WB 1:1000-2000, IHC 1:100-200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
      Tissue specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
      Isotype IgG
      Purification Protein A purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214).

      Images

      monoclonal antibody-Elabscience

      Western Blot analysis of 1) Rat heart, 2) Mouse heart, 3) Hela using STAT3 Monoclonal Antibody at dilution of 1:2000.

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue using STAT3 Monoclonal Antibody at dilution of 1:200.

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Mouse brain tissue using STAT3 Monoclonal Antibody at dilution of 1:200.

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