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ZNHIT3 Polyclonal Antibody

Cat:E-AB-53535
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human esophagus cancer,Human tonsil
Dilution

IHC 1:45-1:300

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Synthetic peptide of human ZNHIT3
Abbre ZNHIT3
Synonyms HNF 4a coactivator ;Thyroid hormone receptor interactor 3;Thyroid receptor interacting protein 3;TR interacting protein 3;TRIP 3;TRIP3;Zinc finger HIT domain containing protein 3;Zinc finger HIT type 3;Zinc finger; HIT domain containing 3;Zinc finger; HIT type containing 3
Swissprot
Concentration 2.4 mg/mL
Buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification Method Antigen affinity purification
Research Areas Epigenetics and Nuclear Signaling; Signal transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Ice bag
background ZNHIT3 (zinc finger, HIT-type containing 3), also known as TRIP3 (thyroid receptor-interacting protein 3) or HNF-4a coactivator, is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR-mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4, and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.