ABCA4 Polyclonal Antibody (E-AB-12935)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human colon cancer, Human thyroid cancer |
| Dilution | IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human ABCA4 |
| Abbre | ABCA4 |
| Synonyms | ABC 10, ABC A4, ABC transporter, ABC10, ABCA 4, ABCA4, ABCR, ARMD 2, ARMD2, ATP binding cassette 10, ATP binding cassette sub family A member 4, ATP binding cassette sub family A member4, ATP binding cassette tr, ATP binding cassette transporter, abcA4, retinal-specific |
| Swissprot | |
| Cellular Localization | Membrane. Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. |
Other Clones
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Other Formats
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Unconjugated
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