ACE2 Monoclonal Antibody(Detector) (AN001680P)
For research use only.
| Verified Samples | Verified Samples in ELISA: Recombinant Human ACE2 protein, Human serum, Human plasma |
| Dilution | ELISA Detector 0.1-0.4 μg/mL |
| Isotype | Rat IgG2a |
| Host | Rat |
| Reactivity | Human |
| Applications | ELISA Detector |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human ACE2 protein expressed by Mammalian |
| Abbre | ACE2 |
| Synonyms | ACEH, ACEII, |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular |
| Clone No. | 1G5 |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
| background | ACE2 (Angiotensin-converting enzyme 2),also named as ACEH,is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE,being found predominantly in the heart,kidneys,and testes although low levels have been detected in a variety of tissues. ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2. The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility,symptoms,and outcome of 2019-nCoV/SARS-CoV-2 infection. It can be used as a potential therapeutic target of SARS-CoV-2. The calculated molecular weight of ACE2 is 92kDa but it migrates to 120kDa due to N-glycosylation . Sometimes,several cleaved fragments can also be detected as 75kDa,50 kDa or 37kDa. It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm,however it accumulates in the nucleus during the mitosis. |
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Unconjugated
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