CASP4 Polyclonal Antibody (D-AB-10447L)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human tonsil, Human colon Verified Samples in IF: Mouse NIH-3T3 |
| Dilution | IHC 1:400-1:800, IF 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human CASP4 protein expressed by E.coli |
| Abbre | CASP4 |
| Synonyms | Apoptotic cysteine protease Mih1/TX, CASP-4, CASP4, Caspase 4 apoptosis related cysteine peptidase, Caspase-4 subunit 2, Caspase4, ICE(rel)-II, ICE(rel)II, ICEREL II, ICH2, Mih1/TX, Protease ICH-2, Protease TX, TX |
| Swissprot | |
| Cellular Localization | Cytosol, AIM2 inflammasome complex, cytosol, IPAF inflammasome complex, NLRP3 inflammasome complex, Endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum membrane, Extracellular region or secreted, extracellular region, Mitochondrion, Plasma Membrane, Other locations: protein complex. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Cell Biology, Metabolism |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the cysteine proteases that plays important roles in apoptosis,cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4,apoptosis-related cysteine peptidase",this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. |
Other Clones
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Other Formats
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Unconjugated
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