CDKN2AIP Polyclonal Antibody (E-AB-10510)
For research use only.
Verified Samples |
Verified Samples in IHC: Human thyroid cancer |
Dilution | IHC 1:50-1:200 |
Isotype | IgG |
Host | Rabbit |
Reactivity | Human |
Applications | IHC |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human CDKN2AIP |
Synonyms | CARF, CDKN2A interacting protein, CDKN2A-interacting protein, Calcium response factor, Cdkn2aip, Collaborator of ARF, FLJ20036, collaborates/cooperates with ARF (alternate reading frame) protein |
Swissprot | |
Cellular Localization | Nucleus>nucleoplasm. |
Concentration | 0.3 mg/mL |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
background | CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus. |
Other Clones
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Other Formats
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Unconjugated
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