Claudin 4 Monoclonal Antibody (ELAB6579-M)
For research use only.
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-P |
| Synonyms | Claudin 4 |
| Cellular Localization | cell membrane |
| Tissue Specificity | Colon cancer |
| Storage | The concentrated should be stored at -20°C protecting from light,Valid for 12 months. |
| Shipping | Ice bag |
| background | Claudin4, a member of the tight junction protein family, is mainly distributed in the cell membrane and cytoplasm of the epithelial cells of the intestinal cavity in normal tissues. It is mainly distributed in the cell membrane in adenomas and in the cell membrane in colorectal cancer. The highest expression was observed in adenomas. Claudin-4 has been shown to distinguish adenocarcinoma from malignant mesothelioma with 99% specificity in malignant effusions. In multivariate analysis of breast cancer, Claudin-4 overexpression was able to independently predict survival, as it was associated with poor prognosis, high tumor grade, and Her2 expression, and was inversely associated with estrogen receptor staining. |
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