CRELD2 Polyclonal Antibody (E-AB-11103)
For research use only.
| Verified Samples |
Verified Samples in WB: Human colon Verified Samples in IHC: Human thyroid cancer, Human gastric cancer |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human CRELD2 |
| Abbre | CRELD2 |
| Synonyms | CREL2, CRELD 2, CRELD2, Cysteine rich with EGF like domain protein 2, Cysteine rich with EGF like domains 2, Cysteine-rich with EGF-like domain protein 2, DKFZp667O055, MGC11256 |
| Swissprot | |
| Calculated MW | 38 kDa |
| Cellular Localization | Secreted. Endoplasmic reticulum. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cell Biology, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development.CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains.Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR 4, possibly regulating its transport.Human CRELD2 shares 69% amino acid identity with its mouse counterpart, suggesting a conserved role between species.Multiple isoforms of CRELD2 exist due to alternative splicing events.The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome.Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. |
Other Clones
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Other Formats
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Unconjugated
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