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For research use only.

Verified Samples Verified Samples in IHC: Human brain
Dilution IHC 1:30-1:150
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human EFNB1
Abbre EFNB1
Synonyms CFND,  CFNS,  Craniofrontonasal syndrome (craniofrontonasal dysplasia),  EFL 3,  EFL-3,  EFL3,  EFNB1,  ELK ligand,  ELK-L,  EPH-related receptor tyrosine kinase ligand 2,  EPLG2,  Elk L,  Eph related receptor tyrosine kinase ligand 2,  Ephrin-B1,  LERK 2,  LERK-2,  LERK2,  Ligand o
Swissprot
Cellular Localization Membrane.
Concentration 0.9 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Cell Biology,  Cardiovascular,  Developmental Biology,  Neuroscience,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.
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Unconjugated

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