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For research use only.

Verified Samples Verified Samples in IHC: Human colorectal cancer, Human cervical cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human GCSH
Abbre GCSH
Synonyms GCE,  GCSH,  Glycine cleavage system H protein,  Glycine cleavage system H protein mitochondrial,  Glycine cleavage system protein H,  Glycine cleavage system protein H (aminomethyl carrier),  Lipoic acid containing protein,  Mitochondrial glycine cl,  mitochondrial
Swissprot
Cellular Localization Mitochondrion.
Concentration 1.08 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Cancer,  Metabolism,  Signal transduction,  Tags & Cell Markers
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.
Other Clones

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Unconjugated

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