Human Aβ1-42 Antibody Pair Set (E-KAB-0447)
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For research use only.
| Background |
Aβ derives from APP via proteolytic cleavage by proteases called α- , β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ , while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein ( APP ) , encoded by APP gene which locate on human chromosome 21q , is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth , neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain , kidney , heart and spleen , but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 ( AD1 ) . This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta.
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| Synonyms |
Aβ ( 1-42 ), Amyloid Beta 42, Amyloid Beta 42
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human Aβ1-42 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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