Human F7 Antibody Pair Set (E-KAB-0540)
For research use only.
| Background |
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form , and is converted to an active form by either factor IXa , factor Xa , factor XIIa , or thrombin by minor proteolysis. Upon activation of the factor VII , a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated , and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions , the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
|
| Synonyms |
FVII, Proconvertin, SPCA
|
| Swissprot | |
| Reactivity |
Human
|
| Specificity |
Detects Human F7 in ELISAs
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| Applications |
ELISA
|
| Storage |
-20℃
|
| Expiration date |
12 months
|
Other Clones
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