IFN-alpha 1 Monoclonal Antibody(Detector) (AN002650P)
For research use only.
| Verified Samples | Verified Samples in ELISA: Recombinant Mouse IFN-alpha 1 protein, Mouse plasma, Cell Lysates |
| Dilution | ELISA Detector 0.1-0.4 μg/mL |
| Isotype | Rat IgM |
| Host | Rat |
| Reactivity | Mouse |
| Applications | ELISA Detector |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse IFN-alpha 1 protein expressed by Mammalian |
| Abbre | IFN-alpha 1 |
| Synonyms | Ifna, IL-1ra Homolog, IFN-α, IL-1F, IL-1L, IL-1HY, IL-1RP, IFN-alpha, FIL1 delta, IFN-alpha-1, IFN-α1, IL-1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1ra Homolog 1, IL-1RP3, Ifna1 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Immunology, Cancer |
| Clone No. | 9B3 |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
| background | The interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, and classified based on their binding specificity to cell surface receptors. The type I IFN bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 ( alpha -subunit) and IFNAR2 ( beta -subunit). This binding contributes to TNF-alpha induced signaling. Both the human and mouse genome code for more than a dozen closely related IFNa subtypes and the varous IFN a share about 80% sequence homology among them. Interferon-alpha 1 (IFNA1) is a secreted, approximately 19 kDa member of the type I interferon family of molecules. Mature mouse IFN-alpha 1 shares 63% and 82% amino acid sequence identity with human and rat IFN-alpha 1, respectively. Low level IFN-alpha is detected under physiological conditions, and the production of IFNs is markedly enhanced during virus infection. Although originally discovered by its capability to fight virus replication, IFN-alpha functions as a prototypic tumor suppressor that represses the clinical tumorigenic phenotype in some malignancies. |
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Unconjugated
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