IL-22 Monoclonal Antibody(Detector) (AN001250P)
For research use only.
| Verified Samples | Verified Samples in ELISA: Recombinant Human IL-22 protein, Human serum, Human plasma |
| Dilution | ELISA Detector 0.1-0.4 μg/mL |
| Isotype | Mouse IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | ELISA Detector |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human IL-22 protein expressed by Mammalian |
| Abbre | IL-22 |
| Synonyms | Cytokine Zcyto18, IL-10-reLated T-ceLL-derived inducibLe factor, IL22, IL-22, IL-D110, IL-TIF, ILTIFIL-10-reLated T-ceLL-derived-inducibLe factor, IL-TIFMGC79382, interLeukin 22, interLeukin-22, MGC79384, TIFa, TIFIL-23, zcyto18 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Immunology |
| Clone No. | 4E6 |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
| background | Interleukin-22 (Il-22),also known as Il-10-related T cell-derived inducible factor (Il-TIF) was initially identified as a gene induced by Il-9 in mouse T cells and mast cells. Mouse Il-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human Il-22 and Il-10,respectively. The mouse Il-22 gene is localized to chromosome 10. Although it exists as a single copy gene in many mouse strains,the Il-22 gene is duplicated in some mouse strains including C57B1/6,FVB and 129. The two mouse genes designated Il-TIF alpha and Il-TIF beta,share greater than 98% sequence homology in their coding region. Il-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. Il-22 is produced by normal mouse T cells upon Con A activation. Mouse Il-22 expression is also induced in various organs upon lipopolysaccharide injection,suggesting that Il-22 may be involved in inflammatory responses. The functional Il-22 receptor complex consists of two receptor subunits,Il-22 R (previously an orphan receptor named CRF2-9) and Il-10 R beta (previously known as CRF2-4),belonging to the class II cytokine receptor family. |
Other Clones
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Other Formats
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Unconjugated
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