Mouse IP-10/CXCL10 Antibody Pair Set (E-KAB-0552)
For research use only.
| Background |
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis , differentiation , and activation of peripheral immune cells , regulation of cell growth , apoptosis and modulation of angiostatic effects.Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites.Mechanistically , binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway , an increase in intracellular calcium production and actin reorganization. In turn , recruitment of activated Th1 lymphocytes occurs at sites of inflammation.Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia , the resident macrophage population of the central nervous system , and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.
|
| Synonyms |
C7, IFI10, INP10, SCYB10, crg-2, gIP-10, mob-1
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| Swissprot | |
| Reactivity |
Mouse
|
| Specificity |
Detects Mouse IP-10/CXCL10 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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Other Clones
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