Nesfatin-1/Nucleobindin-2 Polyclonal Antibody (AN005880L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Mouse brain, Rat brain, Human gastric cancer, Human small intestine |
| Dilution | IHC 1:500-1:1000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human Nesfatin-1/Nucleobindin-2 protein expressed by E.coli |
| Abbre | Nesfatin-1/Nucleobindin-2 |
| Synonyms | DNA-binding protein NEFA, NEFA, NEFAGastric cancer antigen Zg4, Nesfatin1, Nesfatin-1, NUCB2, nucleobindin 2, Nucleobindin-2, nucleobinding 2 |
| Swissprot | |
| Cellular Localization | Golgi apparatus, Membrane, Cytoplasm, Secreted, Endoplasmic reticulum, Nucleus envelope |
| Tissue Specificity | Predominantly expressed in spleen, testis and normal stomach. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Signal Transduction, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
| background | Nesfatin-1 (NEFA Encoded Satiety and Fat-influencing protein 1) is a secreted, 10 kDa peptide derived from the translation product of the NUCB2 gene. Nesfatin-1 is associated with neurons involved in feeding (ARH and PVH) and fluid intake (SON and PVH), in beta cells of the pancreas, and in adipocytes. Its presence peripherally has an anorexigenic effect. Mature human Nesfatin-1 is 82 amino acids (aa) in length. It is the secreted N-terminus of a larger, intracellular 420 aa precursor termed NEFA/Nucleobindin-2/NUCB2. NUCB2 contains a signal sequence (aa 1- 24), Nesfatin-1 (aa 25-106), a DNA-binding site (aa 171-223), and two EF-hand regions (aa 241-276 and 293-328). Intracellular uncleaved NUCB2 is 45-50 kDa in size. There is a potential for multiple cleavages, generating Nesfatin-2 (aa 109-187) and Nesfatin-3 (aa 190-420). Human Nesfatin-1 shares 85% aa identity with mouse Nesfatin-1. |
Other Clones
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Unconjugated
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