Porcine TNF-α Antibody Pair Set (E-KAB-0609)
For research use only.
| Background |
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia , Under certain conditions it can stimulate cell proliferation and induce cell differentiation.Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.Promotes osteoclastogenesis and therefore mediates bone resorption.
|
| Synonyms |
DIF, TNF-alpha, TNFA, TNFSF2
|
| Swissprot | |
| Reactivity |
Porcine
|
| Specificity |
Detects Porcine TNF-α in ELISAs
|
| Applications |
ELISA
|
| Storage |
-20℃
|
| Expiration date |
12 months
|
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