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For research use only.

Verified Samples Verified Samples in WB: HepG2
Verified Samples in IP: HepG2
Dilution WB 1:500-1:2000,  IP 1-4 μL/mg of lysate
Isotype IgG
Host Rabbit
Reactivity Human
Applications WB,  IP
Clonality Rabbit Monoclonal
Immunogen Recombinant Human ASGPR1 protein
Abbre ASGR1
Synonyms ASGR,  C type lectin domain family 4 member H,  CLEC4H,  ASGP-R,  ASGR1,  ASGPR,  ASGPR1,  CLEC4H1,  HL-1,  ASGPR 1,  ASGP-R 1,  Asialoglycoprotein receptor 1,  C type lectin domain family 4 member H1,  C-type lectin domain family 4 member H1,  Hepatic lectin H1
Swissprot
Calculated MW 33 kDa
Observed MW 43 kDa
The actual band is not consistent with the expectation.

Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include:

1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein.

2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes.

3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1.

4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids).

5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers.

If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane.

Concentration 1 mg/mL
Buffer 0.2 μm filtered solution in PBS
Purification Method Protein A
Research Areas Signal Transduction,  Tags & Cell Markers
Clone No. 8C9
Conjugation Unconjugated
Storage This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Shipping Ice bag
background This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Other Clones

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Unconjugated

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